Analysis of enzyme kinetic data for mtDNA replication
نویسندگان
چکیده
منابع مشابه
Analysis and interpretation of enzyme kinetic data
[email protected] Abstract Analysis of enzyme kinetic data to obtain valid information requires attention to two details that are often given less attention than they need. The first is an experimental design that ensures that the variables treated as independent are truly independent, that different interpretations can be distinguished, and that parameter values can be estimated. The second is ...
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Many organophosphorus compounds are irreversible inhibitors of acetylcholinesterase. The methods used in the literature to determine the inhibition kinetic constants usually involve either manual determination of the slope at various points along the inhibition progress curve or fitting polynomials to the curve. The present study investigates the use of non-linear-regression analysis to determi...
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The concerted two-state allosteric model proposed by Monod et al. (Monod, J., Wyman, J., and Changeux, J.-P. (1965) J. Mol. Biol. 12, 88-118) is extended to expressions representing the initial velocity as a function of substrate concentration for two-substrate enzymes for which random substrate binding and rapid equilibration of all binding steps prior to a rate-determining conversion in the t...
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در این پایان نامه نشان داده ایم که چگونه می توان مدل ریسک بیمه ای اسپیرر اندرسون را به کمک زنجیره های مارکوف تعریف کرد. سپس به کمک روش های آنالیز ماتریسی احتمال برشکستگی ، میزان مازاد در هنگام برشکستگی و میزان کسری بودجه در زمان وقوع برشکستگی را محاسبه کرده ایم. هدف ما در این پایان نامه بسیار محاسباتی و کاربردی تر از روش های است که در گذشته برای محاسبه این احتمال ارائه شده است. در ابتدا ما نشا...
15 صفحه اولAncient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the haplogroup carry functional implications and which are "evolutionary silent hitchhikers". We set forth to study the functionality of haplogroup-de...
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ژورنال
عنوان ژورنال: Methods
سال: 2010
ISSN: 1046-2023
DOI: 10.1016/j.ymeth.2010.02.019